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Dr. Nedic explains the dangers of unbalanced metylation to A2 Magazine

Dr. Nedic explains the dangers of unbalanced metylation to A2 Magazine

Nedic Reports, News




Dr. Nedic explains the dangers of unbalanced metylation to A2 Magazine

Methylation is a new buzzword in the anti-ageing and integrative medicine domain,due to an improved understanding of its crucial importance in biological cell metabolism.

It is a process happening a billion times every minute in each cell of our body, particularly in cells that regenerate quickly or are involved in biotransformation – such as the liver and skin.Simply put, it is a process that donates methyl groups from one molecule to another and rules many of the body’s vital activities:

Simply put, it is a process that donates methyl groups from one molecule to another and rules many of the body’s vital activities:

  • turning on and off genes (critical for epigenetic effect and cancers)
  • neurotransmitter metabolism (serotonin, dopamine, norepinephrine, melatonin) and balancing brain chemistry
  • hormone detoxification (particularly estrogen)
  • muscle building and cell membrane formation
  • energy production in mitochondria functioning
  • DNA and RNA synthesis
  • output and recycling of glutathione – the body’s master antioxidant
  • the immune response, controlling T-cell production, fighting infections and viruses, and regulating the immune response
  • nerve myelination.

In discovering in how many critical biological reactions methylation plays a crucial role,it has become accepted that methylation is important for general health and warding off disease, not just ageing. One recent publication revealed that, in the past 10 years, infertility has increased by 40% and this is mostly to blame on inadequate methylation.

Diseases and dysfunctions potentially caused by impaired methylation:

  • Insomnia
  • Autoimmune disorders
  • Premature ageing
  • Multiple sclerosis
  • Anxiety
  • Hashimoto’s
  • Cancer
  • Parkinson’s
  • Diabetes
  • Dementia
  • Fibromyalgia/chronic fatigue syndrome
  • Cardiovascular disease
  • Medication sensitivities
  • Suppressed immune system
  • Allergies
  • Digestive problems
  • Infertility
  • Anxiety and depression
  • Miscarriages

So, what are factors that prevent methylation from working seamlessly? These are the major contributors:

  1. Methylation genetics
  2. Environmental toxins
  3. Micronutrient deficiencies
  4. Methylation abusers
  5. Methylation thieves
  1. Methylation genetics

Since human genomics was identified in 2000, knowledge of our genetic make-up has become so profound that we are now aware that methylation can be hugely compromised by poor genetics. Some 48% of the world’s population has the MTHFR gene,which does not allow folic acid to be utilised in the methylation process,to the detriment of the methylation process. This genetic variation is easy to bypass by using a unique form called 5-methyltetrahydrofolate. If your vitamins contain folic acid of a different form, or if you are not eating plenty of leafy greens and MTHFR positive (50% chance), your methylation is jeopardised.

This is just one gene, and we test about 20 genes crucialfor methylation. Another one that is so important is a gene coding for the enzymes involved in vitaminB12 utilisation that hinders the process (even if you have adequate vitamin B12 intake). Testing these genes is the biggest favour you can do yourself, as you can identify which affected genes need to be bypassed.

  1. Environmental toxins

Environmental toxins are a major cause or contributing factor to the numerous diseases more prevalent today, and why so many people (especially younger ones) are affected by problems like: autoimmune conditions, chronic fatigue, anxiety, recurrent viral infections, infertility, insomnia, premature ageing, etc. Some of these harmfultoxinsare BPAs, phthalates, parabens and other xenobiotics. Heavy metals such as mercury (from eating fish), aluminium (deodorants) and lead (cosmetics) are also hugely present in modern times. Mercury’s interference with the MTR enzyme essential for B12 utilisation in methylation is well documented.

  1. Micronutrient deficiencies

Even if a person is fortunate enough to have impeccable genes, methylation can be affected if there are micronutrients deficiencies essential to the methylation process. These include selenium, copper, magnesium, manganese, calcium, B6 and molybdenum. Sometimes just eating certain foods can lead to micronutrient deficiencies. Excessive sugar intake increases the urinary excretion of magnesium, which is involved in more then 40 biological processes in the body, including methylation.

Dairy products contain xanthine oxidase, which uses up molybdenum necessary for the metabolism of sulfites (part of the methylation cycle). Too many sulfites in the body can have some nasty effects, such as contributing to gut inflammation, anxiety, panic attacks, agitation, brain fog, increased neuronal damage, and triggering histamine release (asthma, allergies, rash).In this case, it is not just important to decrease histaminic food but to restore proper methylation and micronutrient deficiencies.

  1. Methylation abusers

During methylation, we intend to re-methylate homocysteine into SAMe (a crucial molecule that donates methylation groups for various processes).But when we have too much stress, the high formation of free radicals caused by conditions such as leaky gut, obesity, insulin resistance, candida or other infections, leads our body to perceive these as life-threatening situations.The body then sacrifices homocysteine to the pathway designed to create more glutathione to “kill” these free radicals that are controlling these conditions. Naturally, the methylation process and the role of SAMe will be put on hold. This has seriously negative effects, leading to a number of diseases.

Measuring homocysteine is the first step in seeing how well your methylation works. Neither high nor low homocysteine are healthy and can be the first marker that identifies whether your methylation is compromised.

  1. Methylation thieves

Many drugs and even supplements sold over the counter are methylation thieves. One well-known such drug is the birth control pill. It’s no wonder that so many women on birth control develop anxiety, depression, insomnia, an inability to lose weight, and even breast cancer and arteriosclerosis. This could all, in part, be due to inadequate methylation. Alcohol is another big methylation thief. Several drugs interfere with methylation through different mechanisms, including antacids, cholestyramine, methotrexate, metformin, bactrim, antimalarial drugs and phenytoin. Some “natural” supplements are also problematic, like high-dose niacin (vitamin B3), quercetin, etc.

In summary, all these problems that affect your methylation can create above-mentioned diseases and lead to premature aging. Whenever I see premature aging in an individual, I know their methylation is compromised. In integrative medicine, there are tools to identify to what degree methylation is affected and personalised treatments can be formulated to combat this.