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Dermagenetics – Dr Nedic

Dermagenetics – Dr Nedic

Medical Articles, Nedic Reports, News







Age Defying Divas

Four dynamic doctors share their beauty secrets…

Being an aesthetic and anti- aging physician, I am very lucky to have the latest scientific information about anti-aging available to me. I truly believe that all aesthetic treatments should be combined with anti-ageing and integrative medicine. My day starts with 30 minutes of meditation and yoga, preferably with the early morning sun. This helps me to enhance adequate vitamin D production. It also assists with switching off night hormones like melatonin, into day hormones like cortisol. My diet is prescribed using my genetic profile. Since I am not blessed with good genes for detoxification – and my genetic make-up is predisposed to type 2 diabetes – I ensure my diet is exclusively low GL foods.

This includes all organic foods, fruits, and vegetables which do not contain any pesticides, herbicides and xenobiotics. I also don’t smoke, drink alcohol or caffeine. Lastly, I try to allow myself seven to eight hours of peaceful sleep a night.

Given that I’m a 48-year old professional who attends world congress regularly – and spends hours on research – I have to maintain my stress levels at 0 as stress is a silent aging enemy. I strive to look my best as I believe the all important kick start happens at our first morning look in the mirror. If we look good, we can conquer the world! I regularly do Botox® for frown lines, crows feet, and necklines, and for cheek augmentation, I use Juvederm®-Voluma. Obviously, I try to maintain a natural look. For ongoing skin aging prevention, I use Filorga facial rejuvenation as a cryo-meso peel to assure glowing and radiant skin.

I have done Dermogenetic tests for myself to find out the weaknesses of my skin so I can add a topical cream suitable for my genetic makeup. I mostly use Narrative, which is free of Parabens and alcohol. Another plus point is that it’s also organic. From time to time I add Filorga and Neostrata for specific c problems, and I don’t ever miss applying my sunblock. I enhance collagen production by using EC matrix from Metagenics.


Personalized skin care and lifestyle change for healthy looking skin according to your genetic make-up. Dr. Sly Nedic reports

Due to the ever stressful and toxic environment, we live in today, younger people are now suffering from premature skin aging. Some of the characteristics of premature aging include wrinkles; loss of elasticity; sagginess; thinning and skin inflammation (amongst others).

We also see darker skin types suffering from dryness, roughness, and pigmentation as signs of aging, despite well-established beliefs that they are less prone to the aging process. Thanks to the extensive research in the field of skin aging – the old fashioned way of looking at skin aging as chronological aging and photo-ageing – can now be abandoned.

Besides photo-ageing (which is considered a major skin aging factor), there are many other factors involved in the aging process. These factors are also independent of the skin type (Fitzpatrick I-VI). These are: genetic variations of the low penetration genes (which are influenced by lifestyle and nutrition), cellular renewal slow down and longevity cell gene down-regulation (SIRT1), telomeres shortening, toxins overload, nutritional factors, inflammation, hormonal changes, stress and lastly, gut-liver detoxification influence.

Since many patients suffer from premature aging (despite using expensive skin care creams and regularly applying sun block), a generalized approach where we recommend skin care according to maturity of the skin and skin type is failing to deliver results. WHY?

The simple answer is that our genetic makeup was not prepared for this toxic and stressful environment! To identify these low penetrance genes (and to know how lifestyle and nutrition can influence them in a positive and negative way), is a key point in Dermagenetic tests. Sometimes just identifying a gene (such as one that that is involved in detoxification of grilled meat and cigarette smoking) can help a patient to decrease an outbreak of acne. Simply by changing one’s lifestyle, we can influence genes and improve our skin condition.

Genetic variations in skin aging are already widely used, particularly for the personalized prevention of premature skin aging. We test genes that are involved in skin detoxification, oxidative stress, epidermal integrity, inflammation, and melanogenesis.

We now know that the illuminating role in genes CYP1A1 and GSTM1 is in the detoxification process, as well as skin aging in a modern toxic environment. Similarly, the presence of SOD2 and GPX gene variants can elevate oxidative stress in skin fibroblasts, and accelerate aging due to the production of free radicals. MMP1 will create more sagging and ACE more cellulite.

Dermagenetic studies (which has recently become available in South Africa), should be used on any skin type to identify these genes and gene-environment interactions. Dermagenetics help to prescribe personalized nutrition, supplements, lifestyle changes and customized gene induced skin preparations.

Personalized skincare and therapeutic nutrigenetics will lead to fast patient improvement, rather than using a topical cream allocated to the specific c skin type. In addition, oral supplements will target a specific c gene and strict lifestyle changes will influence genes to work ‘in a positive way’.

So, skin aging in a new high-tech toxic and stressful environment is a mirror of a lifestyle… and not just a simple inevitable process depends on the skin type, photo aging and chronological aging. Addressing skin aging should be part of the integrative medical approach, which includes derma genetics; personalized treatments with supplements; lifestyle and nutrition changes; customized skin care products and medical stress management. The generalized approach and topical treatments are simply not enough to keep our skin rejuvenated, glowing and wrinkle free!